Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS focuses on human rights and anti-racism
2017-03-20

Description: "Bongani Majola Tags: Bongani Majola
Prof Bongani Majola and Prof Leon Wessels at
the launch of the FSHRC.
Photo: Supplied

Human rights are part of the dominant moral and political language of our time, and demand a multi-layered scholarly engagement. These discussions influence national and international relations, and set standards for political and democratic practice.

New Centre for Human Rights launched

Since the academic space is a microcosm of society at large, it is crucial that the University of the Free State (UFS) takes part in such scholarly discussions, drawing lessons and crafting solutions from these dialogues.

To this end, the new Free State Centre for Human Rights (FSCHR) was officially launched on 14 March 2017 at the Bloemfontein Campus of the UFS. Professor Bongani Majola, the newly elected chairperson of the South African Human Rights Commission (SAHRC), was the guest speaker at the event. The FSCHR began operating on 1 January 2016, under the leadership of Prof Leon Wessels, founding member of the SAHRC, as the acting director of the centre. 

A priority on the centre’s agenda will be to uphold the February 2011 post-Reitz agreement between the SAHRC and UFS, which was subsequently made an order of the Equality Court. This order compelled the UFS to establish such a centre. The centre presents new opportunities for cooperation between the UFS and SAHRC and other stakeholders to benefit the UFS and the broader community.

Anti-Racism Week marked by IRSJ

The Institute for Reconciliation and Social Justice (IRSJ), in conjunction with the newly-launched FSCHR, the Anti-Racism Network of South Africa (ARNSA), and the Arts and Culture office of Student Affairs presented an event on Friday 17 March 2017 to mark Anti-Racism Week (14-21 March) and Human Rights Day (21 March).

This second annual Anti-Racism Week sees seven days observed for all institutions, organisations, and individuals to fight racism, with each day having an assigned theme, such as ‘Be Aware’ (14 March) and ‘BeCome’ (21 March).

“Battling racism
is a life-long
commitment”
—JC van der Merwe,
Acting Director, IRSJ

JC van der Merwe, Acting Director of the IRSJ, said, “Battling racism is a life-long commitment. It is time for us to tackle the problem head-on. Anti-Racism Week gives us the platform to communicate within the university, within our communities, but also at grassroots level. The idea this year is that we all BeCome champions against racism, not just during this week, but that it will become part of everyday life on our campuses.”



Talented UFS students perform a flash mob dance prior to a collaborative event to mark Anti-Racism Week and Human Rights Day.
Video: UFS Instagram

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept