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13 December 2024 | Story Martinette Brits | Photo Stephen Collett
Dr Francois Jacobs
Dr Francois Jacobs received his Doctor of Philosophy degree in Chemistry on Monday, 9 December.

Dr Francois Jacobs, a 30-year-old PhD graduate, has recently returned from an intensive training workshop in Harwell, Oxford, courtesy of the David Blow Bursary. This prestigious award recognises outstanding African researchers making significant contributions to macromolecular crystallography.

Dr Jacobs earned his Doctor of Philosophy degree in Chemistry on Monday, 9 December. While earning a PhD by the age of 30 was not part of his initial plan, he always aspired to pursue higher education. “From a young age, I had a strong desire to study at university. Once I got there, my ambition shifted towards obtaining a PhD,” he says, reflecting on the journey that led to this remarkable achievement.

Groundbreaking research on cancer and antibiotics

Dr Jacobs’ research addresses some of the most pressing health challenges of our time: cancer and antibiotic resistance. Using crystallography, he investigates the interactions between newly developed anticancer and antibacterial compounds and biological structures such as proteins at the atomic level. This work is vital in combating the growing threat of antibiotic-resistant bacterial infections and advancing cancer treatments.

"For me, it's about seeing humans thrive and reducing the suffering caused by illness," he explains. "I lost my grandmother to cancer, and I hope my work can spare someone else’s loved one from a similar loss."

Prestigious workshop with global experts

The "DLS-CCP4 Data Collection and Structure Solution Workshop," hosted by Diamond Light Source, offered Dr Jacobs an unparalleled opportunity to learn from leading experts in macromolecular crystallography. The workshop covered critical skills such as growing protein and DNA crystals, preventing degradation during data collection, and processing complex data. Participants also gained insights directly from the engineers and scientists behind the facility’s cutting-edge software and synchrotron technology.

“It was an incredible opportunity to learn from some of the brightest minds in the field,” says Dr Jacobs. “Not only did I acquire new skills, but I also forged new collaborations with potential research partners who can help take my work to the next level.”

The David Blow Bursary, which enabled Dr Jacobs to attend this workshop, is awarded to  African researchers conducting impactful macromolecular crystallography studies.

"This training has been transformative," he adds. "It is a fantastic experience for any aspiring researcher, and I’m grateful to have had the chance to learn from these experts. Many researchers who attend workshops like this go on to work at the Diamond Light Source itself. I am eager to see where this training will take me."

A vision for the future

As Dr Jacobs continues his research, he remains driven by the hope that his work will lead to life-saving advancements in healthcare. “I want my research to provide hope and solutions for individuals battling cancer and bacterial infections,” he says.

His achievements exemplify the transformative power of education, research, and collaboration, and his story serves as an inspiration to aspiring researchers across Africa. 

News Archive

Chemistry Department expands its international footprint
2015-10-14

Prof André Roodt

Prof André Roodt from the Department of Chemistry at the University of the Free State has returned from a research visit at the St Petersburg State University in Russia. The research he conducted at the St Petersburg State University is part of a bilateral collaboration agreement between the University of the Free State and St Petersburg State University.

As part of his visit to Russia (from 17 to 28 September 2015), Prof Roodt presented a seminar at St Petersburg State University, and a lecture at the conference titled: International conference on Organometallic and Coordination Chemistry: Achievements and Challenges.

One of the local Russian newspapers quoted Prof Roodt as “world-renowned expert in the study of chemical kinetics and mechanisms of chemical reactions”. His presentation: Are detailed reaction mechanisms really necessary in (applied) organometallic and coordination chemistry' attracted great interest from the St Petersburg chemists.

The bilateral agreement came to life a year ago when the St Petersburg State University chemists won a grant in a competition to create an international research group, the International Laboratory of Organometallic Chemistry. The Laboratory is headed by Prof Vadim Kukushkin of the St Petersburg State University.

In addition to the employees of St Petersburg University, the research group consists of researchers from Portugal, Finland, South Africa, and Azerbaijan. Together, these groups of scientists are working on the problem of non-reactive metal activation molecules. The main theme of the research laboratory is in the catalysis and activation of metal inert molecules which then undergo significant change, and become meaningful to people chemicals, such as drugs.

As part of this initiative, a bilateral collaboration agreement exists between the St Petersburg State University and the UFS (Russian Science Foundation grant 14-43-00017). Students from our university have visited and conducted research at the St Petersburg State University while some of their students visit and research reaction kinetics at the UFS.

Prof Roodt hosted Valeria Burianova, a student from the St Petersburg University. During her visit at the UFS, she learned about response kinetics. A UFS PhD student, Carla Pretorius, joined the group in Russia where she conducted research on the intermetallic rhodium-rhodium interactions for the formation of nano-wires and -plates, with applications in the micro-electronics industry, and a  potential for harvesting sun energy.

The UFS Department of Chemistry extended its international footprint further with three of its students, Mampotsu Tsosane, Petrus Mokolokolo, and Tom Kama, returning from Switzerland after a six-week research visit in the group of Prof Roger Alberto from the University of Zürich. In return, Prof Roodt hosted a Swiss PhD student, Angelo Frei from Zürich, and taught him more about reaction mechanisms.

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