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21 June 2024 | Story André Damons | Photo Suplied
Dr Claudia Ntsapi
Dr Matlakala C Ntsapi is a Senior Lecturer and researcher in the Department of Basic Medical Sciences at the UFS.

A researcher from the University of the Free State (UFS) is investigating the potential benefits of medicinal plants as supplementary treatments for neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases.

The work of Dr Matlakala Claudia Ntsapi, Senior Lecturer in the Department of Basic Medical Sciences at the UFS, focuses on preserving human brain health to delay or prevent age-related conditions.

According to her, while the primary focus is on age-related neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, the bioactive compounds in these medicinal plants may also have therapeutic potential for other neurological disorders, various types of cancers and Type 2 Diabetes. The broad protective effects of these plant-based bioactive compounds could make them relevant in the potential treatment of other diseases involving oxidative stress and inflammation.

She is involved in several multidisciplinary projects, collaborating with research experts from Denmark, the UK, and various national institutions such as the Central University of Technology (CUT), North West University (NWU), and the Stellenbosch University (SUN), as well as colleagues from the UFS. 

The potential of medicinal plants

“In collaboration with experts from our institution, the CUT and SU, who have strong backgrounds in pharmacology and ethnobotany, we are focusing on underexplored medicinal plants and nutraceuticals. These plants contain bioactive compounds with potential neuroprotective properties, which are believed to provide extra health benefits beyond basic nutritional value,” says Dr Ntsapi.

“We hope that these medicinal plants have the potential to preserve cognitive function and slow the progression of neurodegenerative diseases like Alzheimer’s. Specifically, we aim to identify novel therapeutic targets and discover new avenues for intervention that can improve the quality of life for individuals affected by age-related brain conditions,” she says.

Identifying therapeutic targets and discovering new interventions

The bioactive compounds found in selective medicinal plants and nutraceuticals, explains Dr Ntsapi, serve as a promising source of ‘natural’ therapeutics that may be safer and have fewer side effects compared to conventional synthetic drugs. Additionally, the untapped potential of these compounds for neuroprotection and the preservation of brain health could provide innovative therapeutic solutions. These compounds may be used as complementary therapies to existing drugs, which often have limited efficacy on their own, thereby enhancing overall treatment outcomes for neurodegenerative diseases.

“By utilising cutting-edge techniques, such the innovative CelVivo ClinoStar 2 System, we strive to gain insights into the safety and efficacy of underexplored medicinal plants in preserving cognitive function and slowing disease progression.

“By exploring the untapped potential of bioactive compounds found in medicinal plants and nutraceuticals, our research group aims to contribute to the identification of novel therapeutic targets and the discovery of new avenues for intervention to improve the quality of life for individuals affected by age-related brain conditions,” says Dr Ntsapi.

The researchers, in collaboration with others in the UFS School of Clinical Medicine, will develop 3D cell-based models of the human cortex and hippocampus by utilising the CelVivo ClinoStar 2 System. This cutting-edge technology, housed in an easy-to-use CO² incubator, mimics ‘animal model-like’ conditions with low sheer stress, allowing scientists to generate cell-based models that closely resemble real-world conditions.

Dr Ntsapi explains that they will specifically focus on the technologies’ applications in studying age-related neurodegenerative disorders, such as Alzheimer’s disease. The potential impact of this research is immense, as it could contribute to the development of novel therapeutic strategies for combating the debilitating progression of neurodegenerative diseases, and ultimately improving the quality of life for affected individuals.

Hope for the research

“Our hope for this research is to significantly advance our understanding of neurodegenerative disease progression and to develop novel therapeutic strategies that can effectively combat these debilitating conditions. Ultimately, we aim to improve the quality of life for individuals affected by neurodegenerative diseases by preserving cognitive function and slowing disease progression.

“This research will contribute to the knowledge pool in this field, with the potential to lead to groundbreaking discoveries in the treatment of Alzheimer’s disease and other related disorders, potentially contributing to the policy guidelines on how these conditions are managed and treated,” she says.

The international partners from Denmark and the UK have made their expertise and facilities available to postgraduate students from the UFS, some of whom they are co-supervising.

Dr Ntsapi, who is passionate about exploring innovative solutions to address the gradual decline in normal brain function associated with aging, was this year one the university’s nominations for the prestigious 2023/2024 NSTF-South32 Awards, popularly known as the “Science Oscars” of South Africa. 

News Archive

Machinery and equipment to the value of R6 million acquired by UFS Instrumentation Division
2015-07-02

Photo: Supplied

At an information session held on the Bloemfontein Campus, the Instrumentation Division in the Faculty of Natural and Agricultural Sciences at the University of the Free State (UFS) introduced its new Computer Numeral Control (CNC) machines to the value of R6 million.

Initially, the primary aim of the Instrumentation workshop was to design, produce, and maintain special research equipment which is unavailable on the market, mainly for academic departments. The small-scale production focused on producing support material and equipment for research work.

However, with new equipment and machinery the Division now also can deliver a service to corporate companies and external associates.
 
The CNC machines include a 5-axis Vertical Machining Centre from Haas imported from America. This is one of only four in South Africa, with two in Johannesburg and one in Cape Town.  The lathe makes it possible to produce sophisticated parts, which were previously cumbersome and difficult to make. The machines also cover a wide spectrum in the mechanical field such as the the FLOW Water Jet, which cuts a wide variety of material ranging from titanium to wood without utilising heat, thus saving electricity. This makes it possible to cut a wide variety of materials.

With the new machinery now available, the Instrumentation Division is able to perform high quality and quantity production with precision.

“The advantage of the machinery is that it stimulates production, and is much faster and more accurate than the conventional way of doing things,” said Pieter Botes, Head of the Division.

Botes explained that, by having students and professional artisans at the university design and manufacture equipment, costs are reduced when compared with the expensive nature of equipment and tools found in the market. In addition, “the machines broaden the scope of research conducted” said Botes. The technical dynamics of the machinery advances the scientific knowledge needed to operate it, so bridging the gap between theory and practice.

The Central University of Technology, Signs Division Bloemfontein, Product Development Technology Station (PDTS), Maizey’s, and Knottco Truckparts are some of the university’s trade partners.

The workshop collaborates with the Chemistry, Physics, Microbiology, Botany, Agriculture, and Electronics departments, as well as the Institute of Groundwater Studies at the UFS, and others. These departments receive services in the form of pipette stands, containers for test tubes, bottles, laboratory trolleys, stands for cadavers for Anatomy, pump repairs, stainless steel bailers, filaments, and heaters.

The Instrumentation Division is, therefore, a vital support unit for the Faculty of Natural and Agricultural Sciences as well as the university at large.

Companies, institutions, or individuals who need the Division’s expertise may contact Pieter Botes on botespds@ufs.ac.za.

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