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10 November 2025 | Story Precious Shamase | Photo Supplied
Zandile Mncube
Dr Zandile Mncube presenting her research at the International Mountain Conference (IMC2025) at the University of Innsbruck, Austria.

In a remarkable milestone for both her academic and personal journey, Dr Zandile Mncube, a 27-year-old newly conferred PhD graduate from the University of the Free State (UFS), recently presented her research at the prestigious International Mountain Conference (IMC2025), hosted by the University of Innsbruck, Austria. The event marked not only her debut on the global research stage but also her first international trip and first flight – an experience she described as transformative. 

 

A mountain of research: From UFS weather stations to the global stage

Dr Mncube's journey to this international platform began with encouragement from Prof Ralph Clark, Director of the Afromontane Research Unit, and Dr Melissa Hansen, Lecturer in the Department of Geography, who recognised her potential and urged her to submit an abstract to the conference. 

"Prof Clark proposed that I write an abstract for this conference," Dr Mncube explained. “I had been managing the UFS weather stations and had just begun using their data, so I based my abstract on that work.” 

Her submission was accepted, earning her the opportunity to showcase her research alongside an impressive array of global scholars. The IMC2025, held biennially, brings together experts from across the world to discuss diverse aspects of mountain studies. Dr Mncube formed part of a strong South African delegation that included two students from UFS and one from the University of Cape Town (UCT).

"It was inspiring to see how diverse and multidisciplinary the field is," she said. "It was good to see that, as South Africans, we do fit into the global research stage and can hold our own through the quality of our work.”  

 

Vision for the future: expanding research horizons 

Having been part of the UFS community since 2017 - serving in various roles from student assistant to her current practical and research position – Dr Mncube is now looking ahead to further her research career.

"I want to explore more on the research side of things," she shared. “While I’ve gained valuable experience that could lead to lecturing, my immediate goal is to deepen my involvement in research and fieldwork within Geography.”   

 

A transformative experience and a call for greater support

Describing her participation at the IMC as a "transformative experience, both professionally and personally," Dr Mncube reflected on how it broadened her understanding of global scientific collaboration and highlighted the vital contribution of African researchers. 

She noted there remain "notable gaps in data and contextual understanding that African researchers are uniquely positioned to address," particularly in underrepresented mountain regions.

Dr Mncube strongly advocates for more South African students to be supported in attending international conferences. She observed that several of her peers at the IMC had earned recognition through the Southern African Mountain Conference 2025 (SAMC), further illustrating the value of regional and international engagement. 

"If more students are supported to attend conferences like IMC, it could open doors for them to engage in global research and collaborations that extend far beyond our borders," she said. 

Expressing her heartfelt appreciation, she concluded by thanking Prof Clark and Dr Hansen for their guidance and support, which made her international debut possible.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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