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18 August 2021 | Story André Damons | Photo André Damons
Dr Osayande Evbuomwan is a Senior Lecturer and medical specialist in nuclear medicine in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS).

The University of the Free State (UFS) Department of Nuclear Medicine has, for the first time, started using Lutetium 177 PSMA (Lu-177 PSMA) therapy for the treatment of metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer.

The UFS and the Free State province are now joining other South African universities, such as the University of Pretoria, the University of the Witwatersrand, and other provinces in using this method to treat MCRPC patients. 

Dr Osayande Evbuomwan, a Senior Lecturer and medical specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, says they have started treating their first MCRP patient (first cycle) with peptide receptor radionuclide therapy (PRRT) on 15 July. It is the first time that Lutetium 177 PSMA – a type of PRRT used for treating patients with MCRPC – has been used in the Free State. This method is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Expertise and funds are now available for this treatment

Dr Evbuomwan was trained and exposed to this therapy at the University of the Witwatersrand during his registrar training in nuclear medicine. When he joined the UFS in 2019, he – with the always available help of the Head of Department, Dr Gerrit Engelbrecht – pushed for the therapy to be used in the department. 

“We in the Department of Nuclear Medicine are happy that expertise is now available and that some funds have been released for this treatment to commence. The index patient is very sick with MCRPC and was too sick to qualify for first-line chemotherapy. Each patient will need about four-six cycles for complete treatment. The patient is being treated in the Department of Nuclear Medicine at the Universitas Academic Hospital and Annex.” 

“We are hoping that he will be able to complete at least four cycles and respond well to the treatment. We believe that the ability to administer this treatment now is good news for the Free State, as the people of the Free State also deserve to be exposed to this level of treatment. We are hoping that the government will continue to provide more funds for more of these patients to be treated in our facility,” says Dr Evbuomwan.

It was budgeted to treat five patients (20 cycles), with each cycle (just the Lu-177 PSMA) costing more than R50 000. 

A googled image from the internet of a case before, during, and after completing the full course of therapy. The first image is before
treatment and the last image is after completing treatment, while the images in between are during treatment.
(Source: Google) 

Prostate cancer one of the leading causes of morbidity and mortality

Dr Evbuomwan says prostate cancer is one of the leading causes of morbidity and mortality in the world, including South Africa. When it progresses to the advanced stage of MCRPC, the prognosis becomes bad. 

Dr Evbuomwan explains that there are various conventional systemic therapies, including first- and second-line chemotherapy that could be used to treat patients at this bad stage. However, not all patients are fit for chemotherapy. The few who are fit, according to Dr Evbuomwan, usually end up failing the first-line chemotherapy, which has a lot of undesirable side effects and require long-stay hospital admissions. 

Only a few centres are able to offer second-line chemotherapy. So many of these patients end up suffering from prolonged bone pains before eventually dying from the disease.

PRRT is a targeted nuclear medicine therapy that offers the opportunity to deliver very high levels of radiation specifically to cancer cells, because these cancer cells express specific receptors to which certain peptides can bind. This specificity to cancer cells offers the advantage of providing lower doses of radiation and damage to normal organs and tissues, a characteristic that conventional therapies do not offer, explains Dr Evbuomwan.  

According to him, Lutetium 177 PSMA (Lu-177 PSMA) is a type of PRRT used for treating patients with MCRPC, who are not eligible for chemotherapy or have failed first-line chemotherapy. Numerous research studies around the world have proven that this treatment improves quality of life, slows down disease progression, and improves overall survival, with little or very tolerable side effects in most patients. 

The University of Pretoria is one of the pioneers of this treatment in the world, having done a lot of research with it since 2017. Other provinces such as the Western Cape and KwaZulu-Natal have also recently become involved with the therapy. This therapy is expensive and requires a lot of expertise. It also involves the input of a multidisciplinary team (MDT), which must at least include a nuclear medicine physician, a radiation oncologist, and a urologist. The Departments of Urology and Radiation Oncology at the UFS were also instrumental in the initiation of the therapy and form part of the MDT team at the UFS in the management of these patients.

Treatment puts department, university, and hospital on the map

Dr Evbuomwan says the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. “It also creates an avenue for us to gather data for research purposes and for publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients no longer need to travel to other provinces to get the treatment.”

There are plans to expand the treatment to more patients – and hospital management, who were present at the first treatment, are excited and looking forward to the outcome of this current treatment.

Watch video below:

News Archive

Sport results: Tennis, Netball, badminton, athletics
2009-05-05

During the Mega-intervarsity Tournament held at Sun City last week, both the University of the Free State’s (UFS) men’s and women’s tennis teams beat their opponents. The Kovsies women’s team beat the Pukke 15-0, Tukkies 15-1 and Maties 12-5.

The Kovsies men’s team beat their respective opponents as follows: Maties A 12-6, Maties B 15-0, Pukke A 9-7, Tukkies A 14-1 and Pukke B 15-0.

Janine de Kock from KovsieSport said that she was satisfied with these achievements. “For the past two years the women have won the University Sports South Africa (USSA) tournament and now again this tournament. What makes this achievement special is the fact that it was the first tournament that four of the women’s team members played for the UFS.”

“I am also very satisfied with the achievements of the men’s team. They ended sixth in last year’s USSA tournament. This year, at a tournament where the top four universities in terms of tennis were present, they won,” said Janine.
Rensia Henning in action during the Mega-intervarsity Tournament that took place at Sun City last week.
Photos: Jeanine de Kok
 
Netball: Hard work gets rewarded - (April 2009)

Three Kovsies were selected from the South African National Netball team to the Senior Top 12 Team that will represent South Africa at the SPAR Challenge, a three nation’s test series against Botswana and Fiji. These matches will take place towards the end of May in Pretoria.

The three students are Elzet Engelbrecht, Maryka Holtzhausen, en Adele Niemand.


Kovsie students compete at badminton championships

One former student from the University of the Free State (UFS) Chris Dednam, and one current Kovsie student Annari Viljoen are included in the National Badminton Team that represented South Africa from 17 to 24 April 2009 at the All Africa Badminton Championships in Nairobi, Kenya. They also participated in the Kenya International Championships from 25 to 27 April 2009.

Chris Dednam and Annari Viljoen and with them Roelof Dednam, also a former Kovsie student, were included in the team that will participate at the Sudirman Cup in Guangzhou, China. The Sudirman Cup that will take place from 10 to 17 May 2009 is the world mixed team badminton championship and takes place every two years.

Kovsie athletes win medals

Kovsie athletes excelled at the South African Students Athletics Championships (USSA) that was held in Stellenbosch by winning a total of 15 medals.

The medal winners are:
Gold: Thuso Mpuang for the 200m, Johan Cronjè for the 1 500m, Maryna Swanepoel for the half marathon and Marizette Badenhorst for hammer throw.
Silver: Thuso Mpuang for the 100m, Johan Cronjè for the 5 000m, Charles le Roux for triple jump, Ronè Reynecke for the 800m, and Abongile Lerotholi for 1 500m.
Bronze: Kagisho Kumbane for 100m and 200m, Boy Soke for half marathon, Charles le Roux for long jump, Thandi Malindi for the 3 000m steeple chase, and Marike Steyn for triple jump.

In the team competition the Kovsie men’s team received third place and the women’s team fourth place.
 

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