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Experiences of drug-susceptible tuberculosis patients with symptoms of depression and anxiety: a cohort study of new patients in the Free State

CHSR&D researchers: Dr Gladys Kigozi, Prof Christo Heunis Dr Michelle Engelbrecht

The aim of this study is to explore depression and anxiety among new patients on susceptible tuberculosis (TB) treatment in Mangaung Metropolitan District in the Free State. More specifically, the study seeks: 1) to determine the prevalence of symptoms of depression and anxiety at treatment onset, after the intensive treatment phase (2 months) and at the end of treatment (6 months) among new susceptible TB patients; 2) to determine the influence of depression and anxiety on treatment outcomes of patients on susceptible TB treatment; 3) to explore experiences of TB patients with symptoms of depression and/or anxiety — narratives from the ground; and 4) to explore providers’ views of and experiences in managing TB patients with co-morbid depression and anxiety.

A prospective cohort study will be conducted among newly diagnosed susceptible TB patients registered between 1 July and 31 September 2019 in the Mangaung Metropolitan District. Data gathered through surveys and in-depth interviews with patients and key informant interviews with providers, as well as information from patient records will be analysed quantitatively and qualitatively. The study protocol will be submitted for review to the Health Sciences Research Ethics Committee, University of the Free State. Authorisation to conduct the study among patients will be sought from the Free State Department of Health.

Funding: National Research Foundation


  • Situational analysis of the implementation of TB prevention and infection control strategies in Mangaung Metropolitan District (Completed 2016)
  • Tuberculosis prevention through systematic household contact investigation in the Free State, South Africa (Completed 2016)
  • Assessing the implementation of the Integrated School Health Programme (ISHP) in Maluti-a-Phofung (Completed 2016)
  • PROLIFE: Improving TB outcomes by modifying lifestyle behaviours through a brief motivational intervention (Completed 2018)
  • Towards a health-enabling working environment: developing and testing interventions to decrease HIV- and TB-stigma among healthcare workers in the Free State, South Africa
  • Between a rock and a hard place: emotional well-being and work engagement of nurses who moonlight in Free State hospitals


T: +27 51 401 2240 or

Marizanne Cloete: +27 51 401 2592

Katlego Mabulana: +27 51 401 2495
Juanita Hlongwane: +27 51 401 3269

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